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Developmental Pathways to Metabolic Diseases: Metabolic Physiology, Epigenetics and Body Composition in Healthy Overweight and Obese Subjects with a Fixed Range of Body Mass Index in Singapore - To Investigate the Influence of Ethnicity

This studylooks at how the body’s distribution of fat and its functional relationship to other insulin-sensitive tissues such as the skeletal muscles and liver. We hope to have a better understanding of the differences in metabolism and genetic regulation between normal weight and healthy overweight and obese people within any given ethnic group as well as between different ethnic groups.


SAMS1 Q&A

Developmental Pathways to Metabolic Diseases: To investigate the metabolic effects of birth weight on overweight and obese Chinese adults and their responses to weight loss over 16 weeks

Different birth weights may affect a person’s chances of being overweight along with other factors such as genetics, development during childhood, lifestyle and environmental factors. However the extent of how birth weight affects the body’s distribution of fat or the relationship to other insulin-sensitive tissues such as the muscles and liver is not well understood.  In addition, how a person of different birth weight responds to a weight loss program is poorly understood. This research study will help us understand how birth weight affects body composition, nutritional and metabolic effects in relationship to genetic markers and developmental history. Furthermore, we will have a better understanding of birth weight after a weight loss program on these factors.  This will help us in deciding the importance of developmental and genetic pathways in contributing to an individual’s risk of obesity and the response and effectiveness to an intervention.

SAMS2 Q&A

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